Research,

education,

partnership,

excellence...

GeneFluidics, Inc.

School of Engineering

School of Medicine

Key Personnel

Home

DNA-Biosensor

restricted site

for project

investigators only

Probe Design

Microfluidics

System Integration

Clinical Testing

by facsimlie

by e-mail

GeneFluidics, Inc.

School of Medicine

Urology

Pediatrics

Infectious Disease

Microbiology

Biomathematics

West LA VA

School of Engineering

NiH-NiBib

THE PARTNERSHIP

The goal of the research described in this application is to design and test a self-contained, integrated uropathogen microsensor device. This goal can only be accomplished in a multidisciplinary partnership composed of key personnel representing the fields of urology, pediatrics, engineering, and microbiology. Bernard M. Churchill, Chair, Dept. of Pediatric Urology, UCLA School of Medicine, will be the Principal Investigator on this project, and will have overall responsibility for the project and for the clinical testing of the urosensor. Both Bernard Churchill and Edward R. B. McCabe, Chair, Dept. of Pediatrics, UCLA School of Medicine, already participate in the UCLA Combined Spina Bifida Program, where clinical testing of the urosensor will take place. Dr. McCabe will also be involved in molecular probe design and testing. Chih-Ming Ho, Professor of Mechanical and Aerospace Engineering, UCLA School of Engineering, is a leader in MEMS technology, will be primarily responsible for microfluidics. Vincent Gau, President of GeneFluidics, and inventor of the electrochemical microsensor, will be responsible for design and fabrication of the urosensor device. Warren Grundfest, Chair of the Biomedical Engineering Program at the UCLA School of Engineering will be responsible for integration of the microfluidics and sensor components of the device. David A. Haake, Division of Infectious Diseases, Dept. of Medicine, UCLA School of Medicine, will be responsible for microbiology aspects of microfluidics, probe design, device integration, and UTI correlates. David Bruckner, Chief, Director of the Clinical Microbiology Laboratory, Dept. of Pathology and Laboratory Medicine, UCLA School of Medicine will be involved in probe design, and microbiology aspects of analytic validity testing, and clinical testing of the urosensor. Elliot Landaw, Chair of Biomathematics, is responsible for optimization of probe design and application of biostatistical techniques and data interpretation in the clinical testing of the urosensor.

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