Elliot
M. Landaw
Department of Biomathematics
David Geffen School of Medicine at UCLA
Box 951766
Los Angeles, CA 90095-1766
fax (310)825-8685
email elandaw@biomath.medsch.ucla.edu
Educational Background:
Rutgers UniversityUniversity of ChicagoUniversity of California, Los Angeles B.A.. M.D. Ph.D. 1968 1972 1980 Biological Sciences Medicine Biomathematics
BIBLIOGRAPHY (Selected)
1. Pardridge WM and Landaw EM (1984). Tracer kinetic model of blood-brain barrier transport of plasma protein-bound ligands - Empiric testing of the free hormone hypothesis. J. Clin. Invest. 74:745-752.
2. Landaw E, Chen B, and DiStefano JJ 3d (1984). An algorithm for the identifiable parameter combinations of the general mammillary compartmental model. Mathematical Biosciences 72:199?212.
3. Landaw EM (1985). Robust sampling designs for compartmental models under large prior eigenvalue uncertainties. In Mathematics and Computers in Biomedical Applications, J. Eisenfeld and C. DeLisi (Eds.), Elsevier Science (North? Holland), 181?187.
4. Chen BC, Landaw EM, and DiStefano JJ 3d (1985). Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models. Mathematical Biosciences 76:59?68.
5. Pardridge WM and Landaw EM (1985). Testosterone transport in brain: Primary role of plasma protein?bound hormone. Am. J. Physiology 249,(Endocrinol. Metab. 12):E534?E542.
6. Cobelli C, Ruggeri A, DiStefano JJ 3d, and Landaw EM (1985). Optimal design of multioutput sampling schedules: Software and applications to endocrine?metabolic models. IEEE Transactions on Biomedical Engineering BME?32:249?256.
7. Bahn MM and Landaw EM (1987). A minimax approach to the single point method of drug dosing. J. of Pharmacokin. and Biopharmaceutics 15:255?269.
8. Pardridge WM and Landaw EM (1987). Steady state model of 3,5,3'?triiodothyronine transport in liver predicts high cellular exchangeable hormone concentration relative to in vitro free hormone concentration. Endocrinology 120:1059?1068.
9. DiStefano JJ 3d, Chen BC, and Landaw EM (1987). Pool size and mass flux bounds and quasiidentifiability relations for catenary models. Mathematical Biosciences 88:1?14.
10. Lindell R, DiStefano JJ 3d, and Landaw EM (1988). Statistical variability of parameter bounds for n?pool unidentifiable mammillary and catenary compartmental models. Math. Biosciences 91:175?199.
11. Barstow TJ, Cooper DM, Sobel EM, Landaw EM, and Epstein S (1990). Influence of increased metabolic rate of [13C]-bicarbonate washout kinetics. Am. J. of Physiology (Regulatory Integrative Comp. Physiol.) 259:R163-R171.
12. Armon Y, Cooper DM, Springer C, Barstow TJ, Rahimizadeh H, Landaw EM, and Epstein S (1990). Oral 13C-bicarbonate measurement of CO2 stores and dynamics in children and adults. J. Applied Physiology 69:1754-1760.
13. Mohan OE, Cooper DM, Jensen SC, Armon Y, and Landaw EM (1991). 13CO2 washout kinetics in acute hypercapnia. Respiration Physiology 86:159?170.
14. Barstow TJ, Landaw EM, Springer C, and Cooper DM (1992). Increase in bicarbonate stores with exercise. Respiration Physiology 87:231?242.
15. Marino AT, Distefano JJ 3d, and Landaw EM (1992). DIMSUM: an expert system for multiexponential model discrimination. Am. Journal of Physiology 262 (Endocrinol. Metab. 25):E546?E556.
16. Zanconato S, Cooper DM, Barstow TJ, and Landaw E (1992). 13CO2 washout dynamics during intermittent exercise in children and adults. J. Applied Physiology 73:2476-2482.
17. Cho AK, Hiramatsu M, Schmitz DA, Landaw EM, Chang AS, Ramamurthy S, and Jenden DJ (1993). A pharmacokinetic study of phenylcyclohexyldiethylamine (PCDE): an analog of phencyclidine. Drug Metabolism and Disposition 21:125-132.
18. Bickel U, Yoshikawa T, Landaw EM, Faull KF, and Pardridge WM (1993). Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery. Proc. Natl. Acad. Sci. 90:2618-2622.
19. Cho AK, Hiramatsu M, Schmitz DA, Vargas HM, and Landaw EM (1993). A behavioral and pharmacokinetic study of the actions of phenylcyclohexyldiethylamine (PCDE) and its active metabolite, phenylcyclohexylethylamine (PCE). J. Pharmacol. Exp. Ther. 264:1401-1405.
20. Paquette RL, Landaw EM, Pierre RV, Kahan J, Lubbert M, Lazcano O, Isaac G, McCormick F, Koeffler HP (1993). N?ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome. Blood 82:590?9.
21. Todd K, Wiley F, Landaw E, Gajewski J, Bellamy PE, Harrison RE, Brill JE, Feig SA (1994). Survival outcome among 54 intubated pediatric bone marrow transplant patients. Critical Care Medicine 22:171-176.
22. Chambliss CR, Mohan O, Moromisato M, Garner DJ, Landaw EM, Cooper DM (1994). Exchange of CO2 and bicarbonate between the circulation and CSF in piglets. Am. J. Respir. Crit. Care Med. 150:503-9.
23. Geffner ME, VanDop C, Kovacs AA, Yeh DY, Stiehm ER, Bryson YJ, Israele V, Landaw EM (1994). Intrauterine and postnatal growth in children born to women infected with HIV. Pediatric AIDS and HIV Infection - Fetus to Adolescent 5:162-168.
24. Landaw EM (1994). Model-based adaptive control for cancer chemotherapy with suramin. in Anderson JG and Katzper M (eds.) Proceedings of the Simulation in Health Sciences Conference, pp 93-98; Society for Computer Simulation, San Diego.
25. Landaw EM, Belldegrun AS, McBride JH, deKernion JB, Rosen PJ (1994). Significant intrapatient and interpatient variability of suramin pharmacokinetics in prostate cancer. Proceedings of Am. Assoc. for Cancer Research 35:242.
26. Grovas A, Feig SA, O'Rourke S, Valentino L, Wiley F, Hunt L, Landaw EM, Gajewski J (1994). Unrelated donor bone marrow transplants in children. Cell Transplantation 3:413-420.
27. Cornford EM, Hyman S, Landaw EM (1994). Developmental modulation of blood-brain-barrier glucose transport in the rabbit. Brain Research 663:7-18.
28. Liu WV, Landaw EM, Froines JR (1995): Comparison of the dynamic behavior of compartmental models for lead distribution in the human body. Occupational Hygiene 1:293-304.
29. Rosen PJ, Mendoza EF, Landaw EM, Mondino B, Graves MC, McBride JH, Turcillo P, deKernion J, Belldegrun A (1996). Suramin in hormone-refractory metastatic prostate cancer: a drug with limited efficacy. Journal of Clinical Oncology 14:1626-1636.
30. Walker WL, Landaw EM, Dickerson RE, Goodsell DS (1997). Estimation of the DNA sequence discriminatory ability of hairpin-linked lexitropsins. Proc. Natl. Acad. Sci. 94:5634-5639.
31. Cornford, EM, Hyman S, Cornford ME, Landaw EM, Delgado-Escueta AV (1998). Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier. J. Cereb. Blood Flow Metab. 18:26-42
32. Walker WL, Landaw EM, Dickerson RE, Goodsell DS (1998). The theoretical limits of DNA sequence discrimination by linked polyamides. Proc. Natl. Acad. Sci. 95:4315-4320.
33. Cornford EM, Gee MN, Swartz BE, Mandelkern MA, Blahd WH, Landaw EM, Delgado-Escueta AV (1998). Dynamic [18F]fluorodeoxyglucose positron emission tomography and hypometabolic zones in seizures: reduced capillary influx. Ann. Neurol. 43:801-808.
34. Paquette RL, Tran L, Landaw EM (1998). Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft versus host disease prophylaxis. Bone Marrow Trans 22:351-7.
35. Walker WL, Goodsell DS, Landaw EM (1998). An analysis of a class of DNA sequence reading molecules. J of Computational Biology 5:571-583.
36. Greenword AC, Landaw EM, Brown TH (1999). Testing the fit of a quantal model of neurotransmission. Biophys J. 76:1847-1855.
37. Walker WL, Goodsell DS, Dickerson RE, Landaw EM (1999). A preliminary multiobjective analysis of the chemotherapeutic benefits of hairpin-linked polyamides. The IMA Volumes in Mathematics and its Applications. 108:81-92. (in Rational Drug Design; eds. Truhlar DG, Howe WJ, Hopfinger AJ, Blaney J, and Dammkoehler RA. Springer-Verlag, New York.).
38. Lopez AM, Pegram MD, Slamon DJ, Landaw EM (1999). A model-based approach for assessing in vivo combination therapy interactions. Proc. Natl. Acad. Sci. 96:13023-13028.
39. Coloma MJ, Lee HJ, Kurihara A, Landaw EM, Boado RJ, Morrison SL, Pardridge WM (2000). Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharmaceutical Research 17:265-273.
40. Cornford EM, Nguyen EV, Landaw EM (2000). Acute upregulation of blood-brain barrier glucose transporter activity in seizures. Am. J. Physiol. Heart Circ. Physiol. 279(3):H1346-54.
41. Petz LD, Garratty G, Calhoun L, Clark BD, Terasaki PI, Gresens C, Gornbein JA, Landaw EM, Smith R, Cecka JM (2000). Selecting donors of platelets for refractory patients on the basis of HLA antibody specif
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